Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > GSAP(Gene name) > Mouse
  • Add your favorite
  • GSAP (Gene name),
  • Gamma-secretase-activating protein (Protein name ),  GSAP_MOUSE from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Feedback
  • Gene name:
    GSAP(PION);
    Protein name:
    Gamma-secretase-activating protein(GSAP);
    Alternative:
    Protein pigeon homolog;
    Organism:
    GSAP (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with APP; specifically interacts with the CTF-alpha product of APP. Interacts with the gamma-secretase complex.
    Function:
    Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta-amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.
    Subcellular Location:
    Golgi apparatus trans-Golgi network
    Protein Attributes:
    Sequence length:
    858
    Sequence:
    50:
    MALRLVTHFD | VLEDVLPSLL | TQAATTDEGD | RAGVLETTYG | SLRVLNIERN | 
    100:
    GNIIYTYKDN | KGNAVFGLYD | CQTRQNEHLY | TFEKDMQAVS | CSVNSERTVL | 
    150:
    AASFIQYTTE | GVKNDLQPGS | KCLTLLVEIH | PVNNVKVLKA | VDSCVWVQFL | 
    200:
    YPQAESHLLP | QNHLLLISEE | KYIERFHIQI | TREDGDRVVI | RNSSHLPRDR | 
    250:
    LAEDFVWAQW | DLSEQRLYYI | ELKESRSILK | CIQFRADESF | NLMFEMPLDI | 
    300:
    TLTGLRFKLV | NFGYDYRQDR | EKLCNQPSLC | IFTNHTGSLC | MCYSPKSDSR | 
    350:
    EEITYSVFYL | HKGYRKIFTA | APGSADSQVT | NGADSQVTDG | IAFLNLGYFV | 
    400:
    AVYSPGHFLH | LLNIQHPDLV | CHSLFLTGNN | KIAAVLPPSP | LQSLPGSLVL | 
    450:
    DCYSGKVYRV | TLDQSYLLRF | LWNAHLDCER | MAALHCILSC | SQDPGFPEEQ | 
    500:
    IIQWISEHVS | ACHSFDLIQE | FLIASSYWSV | YAELDDMGML | LQYSSVLTWN | 
    550:
    TEIPGIKFTT | EELPLPLMKV | YGLKGYWAKL | NSNLEYIKYT | KPHLHYHNSV | 
    600:
    VRREWHNLIS | EERTGKRRST | MYVRNILENA | MKVIASMETR | TLEPRLIPFL | 
    650:
    QEEDRHQRLL | MGLMVSELRD | HLLRHLQGVE | KKKIEQMVLD | YISKLLDLIW | 
    700:
    CLLETSWRKH | SMHPLVLHLN | SHCSAADFEV | FHLMTRILDA | ASSLCLPLPP | 
    750:
    GFHSLHTILG | VHCLPLYSLL | HYIDNGVLLL | TETAVTRLMK | DLDNSEKNEQ | 
    800:
    LKFSIIVRLP | PLIGQKVCRL | WDHPMSSNII | SRNHVARLLK | NYRKEPRNSM | 
    850:
    IDKSSFPVEF | LPLNYFIEIL | MGLESSNQAL | YGFEGHDNVD | AEFVEEAALK | 
    858:
    HTTMLLGL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse GSAP
    Cat.:
    E2079h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse GSAP
    Cat.:
    E2079m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse GSAP
    Cat.:
    U2079h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse GSAP
    Cat.:
    U2079m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse GSAP
    Cat.:
    P2079Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse GSAP
    Cat.:
    P2079Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse GSAP
    Monoclonal Antibody for Mouse GSAP
    Protein for Mouse GSAP
    Protein for Mouse GSAP

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      strain: NOD.
      tissue: Aorta.
      tissue: Bone.
      tissue: Cecum.
      tissue: Vein.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Eye.
    3. 3.
      "Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease."
      He G. , Luo W. , Li P. , Remmers C. , Netzer W.J. , Hendrick J. , Bettayeb K. , Flajolet M. , Gorelick F. , Wennogle L.P. , Greengard P.
      Nature467:95-98(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    Product Feedback Wall
    Hot Genes
    Atf2 ASPRO ACE ALCAM C19orf80 Trap1a Gdf5
    Top Searches
    Ubiquitin-protein ligase metalloproteinase Ubiquitin ELISA Alpha Tumor necrosis Asprosin TRAP1A
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.com.cn

    Copyright & copy www.eiaab.com2006-2026 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    鄂ICP备10015095号-1

    鄂公网安备 42018502005535号

    Twitter